In the 1960s, Hayflick found that human cells divide only 40 to 60 times, after which they stop — even when their division is paused and then allowed to resume. This discovery, called the Hayflick Limit, indicates that even if a drug like metformin were effective at suspending aging, the end game stays the same.Aging is normalDr. Jonathan Flacker, an internist in geriatrics at Emory University Hospital in Atlanta, said aging is simply not the same as an illness.“A disease is something not normal that some people get but not everybody gets,” he said. “The implication is that aging is abnormal and something nature didn’t intend.”Flacker is not terribly impressed with age-slowing drugs like metformin, either.“We’ll see,” he said. “The mechanisms that control aging are very fundamental and I think it likely that in trying to modify those pathways there will be some significant unanticipated consequences, but that’s why we have such studies in the first place.” While there is no formal campaign to add aging to the official list of diseases, new medical discoveries have opened the discussion. For instance, after studies showed that metformin, a common diabetes drug, could extend lifespan in rodents, researchers went to the federal Food and Drug Administration in June and won approval for human trials of the drug’s anti-aging properties.But there’s no assurance that the FDA would approve an anti-aging drug, even if the clinical trials are positive. The agency has never allowed such a drug on the market, because aging hasn’t been designated as a condition needing treatment.advertisement Experts interviewed by STAT differ on whether aging should be viewed as a disease, the extent to which it’s treatable — and whether doing so can help people live longer. Here’s what they had to say.Aging is a diseaseBiophysicist Alex Zhavoronkov believes that aging should be considered a disease. His company, Baltimore-based Insilico Medicine, Inc., is working on technologies around drugs to treat age-related illnesses. Zhavoronkov said that describing aging as a disease creates incentives to develop treatments. By Leah Samuel Dec. 29, 2015 Reprints Related: New medical discoveries have opened the discussion about whether aging should be added to the World Health Organization’s official list of diseases. Sebastien Bozon/AFP/Getty Images Hillary Clinton proposes funding surge to help cure Alzheimer’s by 2025 HealthCan we ‘cure’ aging? Scientists disagree Related: A progress report: Fighting the deadliest diseases, one step at a time Related: “It unties the hands of the pharmaceutical industry so that they can begin treating the disease and not just the side effects,” he said.“Right now, [people] think of aging as natural and something you can’t control,” he said. “In academia, people take aging research as just an interest area where they can try to develop interventions. The medical community also takes aging for granted, and can do nothing about it except keep people within a certain health range.”But if aging were recognized as a disease, he said, “it would attract funding and change the way we do health care.”Aging can be curedAubrey de Grey also advocates going after aging itself. He is chief science officer for the SENS Research Foundation, which conducts and funds research on regenerative medicine.“I don’t actually say aging is a disease,” he said. “Aging is bad for you, it’s a medical problem, but that’s just language.”What matters, de Grey added, is understanding that aging is curable.“It was always known that the body accumulates damage,” he said. “The only way to cure aging is to find ways to repair that damage. I think of it as preventive medicine for age-related conditions.”De Grey added that he is intrigued by the skepticism he finds.“It’s a curious thing, ” he said. “If you fix one disease of aging, that’s wonderful. If you fix two diseases, that’s wonderful.”Our lifespan is limitedLeonard Hayflick, a professor of anatomy at the University of California, San Francisco, said the idea that aging can be cured implies the human lifespan can be increased, which some researchers suggest is possible. Hayflick is not among them.“There are many people who recover from cancer, stroke, or cardiovascular disease. But they continue to age, because aging is separate from their disease,” Hayflick said. He added that even if those causes of death were eliminated, life expectancy “would still not go much beyond 92 years.” Patients aren’t told that death is near until too late. We can do better Aging happens to all of us, and is generally thought of as a natural part of life. It would seem silly to call such a thing a “disease.”On the other hand, scientists are increasingly learning that aging and biological age are two different things, and that the former is a key risk factor for conditions such as heart disease, cancer, arthritis, Alzheimer’s disease, and many more. In that light, aging itself might be seen as something treatable, the way you would treat high blood pressure or a vitamin deficiency.Those two are in the current International Classification of Diseases (ICD), a manual published by the World Heath Organization — but aging is not. The next revision of the manual is due out in 2018.advertisement Tags agingFDAgeriatrics
The recession is taking its toll not only on businesses and unemployed Americans—it’s also affecting the employees still reporting to work, day in and day out. In fact, the stresses have grown so great that workers are starting crack under the pressure. Employees are reporting thoughts of suicide, violence against co-workers and mental breakdowns at the highest rates seen in three years, according to Harris, Rothenberg International (HRI), a provider of employee assistance program (EAP) services. As companies try to do more with fewer workers, employees are stretching themselves thin to meet the demands at the workplace, with their families and for themselves, said Julie LeBlanc, HRI’s associate director of clinical services, in an interviewwith SHRM Online. “This is a new kind of stress. Before, when people were worried, they could take time off. Now they are scared of losing their jobs and can’t take off,” LeBlanc said. “They are not taking vacations, they are always in the office, they aren’t taking lunch. People try to ‘white-knuckle’ it through, and then one stressor too many happens and they fall apart. When work/life balance is not a priority, HRI said in a press statement, employees skimp on sleep, exercise, therapy and family time—to their extreme detriment. “Employees don’t realize why they are stressed and they forget about self care,” LeBlanc told SHRM Online. “Think it through—take a 30-minute lunch break by yourself, walk around the building, eat and sleep well. Don’t use substances [such as alcohol or drugs]. Drink enough water. People don’t think of those things, but you can only do this so long before your body gives out.” Supervisors, too, need to be in tune with their employees’ needs. Follow these tips from HRI to help spot and address worrisome employee behavior: *Address concerning behaviors you see in employees early on, linking them to mental health resources like their EAP and to work/life programs. *Encourage the use of your company’s time off and sick leave policies, as well as other benefits that will help the wellness of employees. *Train mangers on recognizing the signs of mental health and substance abuse distress, and give them tools for helping their direct reports. *Offer mental health screenings in employee health and benefits fairs. *Incorporate wellness, resilience and morale-enhancing events into the workplace, such as social gatherings, teambuilding exercises, and yoga/fitness/nutrition clubs or services. *Promote company benefits often so employees make use of the resources available to them. Beth Mirza is senior editor for HR News. She reports on Business Leadership, Safety & Security and other HR issues. Prior to coming to SHRM in 2001, Beth worked for community newspapers in Northern Virginia. Follow her on Twitter @BethMirza.
Do we want to be champions or GROs? – Sotto Don’t miss out on the latest news and information. BeautyMNL open its first mall pop-up packed with freebies, discounts, and other exclusives For the complete collegiate sports coverage including scores, schedules and stories, visit Inquirer Varsity. Sports Related Videospowered by AdSparcRead Next LATEST STORIES SEA Games: PH still winless in netball after loss to Thais ‘A complete lie:’ Drilon refutes ‘blabbermouth’ Salo’s claims Photo by Tristan Tamayo/ INQUIRER.netNCAA Season 93 Juniors Most Valuable Player Will Gozum is set for a homecoming.The former Mapua Red Robin returns to Diliman as he has committed to play for University of the Philippines.ADVERTISEMENT View comments Gozum partners with Nigerian center Bright Akhuetie up front UAAP Season 81 as he joins a Fighting Maroons squad that boasts of potential with team captain Paul Desiderio and returnees Jun Manzo, Javi Gomez de Liaño, and UAAP Season 80 Rookie of the Year Juan Gomez de Liaño leading the way.Transferring from UPIS to Mapua, the 6-foot-6 Gozum made a name for himself in the NCAA, averaging 13.2 points, 10 rebounds, and 2.6 blocks in his senior year with the Red Robins.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSBoxers Pacquiao, Petecio torchbearers for SEA Games openingHis stellar showing also earned him an invite to Gilas Pilipinas coach Chot Reyes’ “23-for-23” cadet list in preparation for the 2023 Fiba World Cup.For now, Gozum will reunite with the Gomez de Liaño brothers, his former teammates in the Junior Maroons, this time under the guidance of coach Bo Perasol. MOST READ Hotel says PH coach apologized for ‘kikiam for breakfast’ claim UP is coming off a fifth place finish this past UAAP Season 80 with its 6-8 record. Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles02:14Galvez OK with ‘selective’ martial law in Mindanao02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Win ‘feels like loss’ for Gab Banal, Marinerong Pilipino ‘We cannot afford to fail’ as SEA Games host – Duterte PH military to look into China’s possible security threat to power grid Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’
Wrestling and boxing might not be that influential as sports in our country, but B-Town is clearly eager to tap into the potential of the games in their films. With Priyanka Chopra’s Mary Kom, Bollywood has started following the trend of such films which portray boxing, wrestling or Mixed Martial Arts. The latest one to join this club is Akshay Kumar and Sidharth Malhotra’s Brothers.RELATED: Apart from sibling rivalry, all forms of Mixed Martial Arts too in Brothers Brothers is the remake of the 2011 Hollywood film Warriors. It is a tale of two estranged brothers (David Fernandes and Monty Fernandes), who, in order to prove themselves, are ready to fight each other inside the boxing ring. The film also stars Jacqueline Fernandez in a pivotal role. It is the first time that the trio would be seen together on the silver screen. Akshay is well-trained in Martial Arts, but still found preparing to play David in Brothers a difficult task. As for Sidharth, the boxing and MMA sequences were not exactly a cakewalk for the actor, as the Brothers’ team has repeatedly emphasised.WATCH: Akshay and Sidharth in an emotional song Gaye Jaa from Brothers Here are some other recent films that have had and are portraying wrestling and boxing on the silver screen: Mary Kom The 2014 Mary Kom was based on the life of Mangte Chungneijang Mary Kom, the champion boxer from Manipur. Director Omung Kumar’s film is an account of what actually happened in Kom’s life, all the troubles which she has had to face, and everything else that made Mary Kom a name to reckon with in the boxing scene of the country. Piyanka Chopra played the real life five-time world boxing champion, and totally nailed the character. The film was much appreciated by the audience and claimed numerous awards as well.advertisement Dangal Aamir Khan is also not far behind, as far as displaying wrestling in Hindi films is concerned. He plays the real life wrestler Mahavir Phogat in his next film, Dangal. In fact, he’ll be playing father to two grown-up daughters (Babita Kumari and Geeta Phogat) who play boxers in the film. There were a lot of rumours that Kangana Ranaut and Taapsee Pannu were also a part of this script, but all were rubbished by Aamir. Bollywood debudants Fatima Sana Shaikh and Sanya Malhotra have been roped in for the roles of the two daughters in Dangal.Aamir gained around 22kgs for Dangal Sultan On his part, Salman too is not far behind vis-a-vis portraying wrestling in films. He is wooing his fans with his forthcoming film Sultan, which is the tale of a wrestler from Haryana. The teaser of Sultan was released a few weeks back. The teaser glorified Sultan the wrestler to the T – ‘Haryana ki shaan, Haryana ka sher, Haryana ki jaan… Sultan Ali Khan.. jab vo ring mein move karta hai, toh aisa lagta hai maano dance kar raha ho’. The film has created a lot of buzz already because of its clash with Shah Rukh Khan’s Raees. The shooting of Sultan will begin in November this year, while director Abbas Ali Zafar has already begun hunting for locations for the film. It is expected to hit the screens on Eid 2016. Holiday Yes, the film had as its theme terrorism and patriotism, but had the Dabangg Girl Sonakshi Sinha, who played the role of a boxer in the film. Holiday did not really focus on the sport as such, but was a delight to see actors like Sonakshi and Priyanka taking up such roles in their movies.
Image Courtesy: Hapag-LloydIn today’s spotted, we bring you an image of Santos Express, a Neopanamax containership which was recently delivered to German shipping company Hapag-Lloyd from South Korean Hyundai Samho Heavy Industries shipyard. The 10,500 TEU boxship will soon be ready to ship cargo between Europe and South America, Hapag-Lloyd said.With a gross tonnage of 116,000 tons, the newbuilding features a length of 333 meters and a width of 48 meters.Santos Express, which flies the flag of Germany, has a market value of USD 80.8 million, according to data provided by VesselsValue.As of December 31, 2016, Hapag-Lloyd’s fleet comprised a total of 166 containerships with a total capacity of 1 million TEU.World Maritime News Staff
Kinder Morgan, meanwhile, has given Trudeau until the end of May to find a solution that would provide their investors a measure of confidence that the project would be allowed to proceed.The meeting, convened at the last minute Thursday as Trudeau was departing for the Summit of the Americas in Peru, marked the first time the three leaders have all been in the same room together to hash out the dispute.(THE CANADIAN PRESS) OTTAWA, O.N. – B.C. Premier John Horgan says his meeting with Prime Minister Justin Trudeau and Alberta Premier Rachel Notley did nothing to end his ongoing efforts to block plans to expand an existing diluted bitumen line between the two provinces.Horgan, Alberta counterpart Rachel Notley and Prime Minister Justin Trudeau met today on Parliament Hill in hopes of finding a solution to the impasse between the two provinces, which is threatening to kill the expansion project.Horgan says Trudeau laid out “legislative and financial measures” to push the project forward, but he did not elaborate. Privy Council Clerk Michael Wernick, Finance Minister Bill Morneau and Natural Resources Minister Jim Carr also took part in the meeting.Horgan’s opposition to Trans Mountain, rooted in part in the fact his tenuous NDP government depends on the support of the Green party, which staunchly opposes the project, is the main reason Kinder Morgan put the brakes on non-essential spending on theproject a week ago.Trudeau insists the Kinder Morgan pipeline is within federal jurisdiction and that Horgan’s government has no authority to block it, a claim Horgan wants the courts to evaluate, and one he says he plans to press ahead with.Trudeau’s cabinet approved the pipeline in 2016, following an interim environmental review process that included assessing things such as the emissions that will be created from producing additional fossil fuels that will flow through it. The cabinet decided the project, which will build a new pipeline that runs parallel to an existing one but can carry twice as much, was in the national interest.Trudeau has argued repeatedly his government has put in place the environmental protections and policies needed to reduce the risks of an oil spill, and that building the pipeline to get Canadian resources to market is necessary for the Canadian economy.Notley says Alberta will buy an equity stake in the pipeline or even buy the whole thing if necessary.
New Delhi: Lenders of debt-ridden Ruchi Soya will vote on April 30 to decide on Baba Ramdev-led Patanjali Ayurved’s revised Rs 4,350 crore bid for the edible oil firm, sources said. Patanjali, the lone player left in contention after the exit of Adani Wilmar, had last month increased its bid value by around Rs 200 crore to Rs 4,350 crore for the Madhya Pradesh-based Ruchi Soya. This excludes capital infusion of Rs 1,700 crore into the company. Sources said the Committee of Creditors (CoC) met on Friday to discuss the revised bid of Patanjali and decided to conduct the voting process on April 30. Ruchi Soya Industries owes around Rs 9,345 crore to financial creditors and another Rs 2,750 crore to operational creditors. In December 2017, the National Company Law Tribunal (NCLT) had referred Ruchi Soya for insolvency proceedings on the application of financial creditors Standard Chartered Bank and DBS Bank.
Kolkata: The body of a jute mill labour was found at Manirampur in Barrackpore on Wednesday night. In another incident, a youth was murdered in Nimta on Wednesday night.According to sources, Kamal Das (58) a resident of Manirampur in Barrackpore used to work in a jute mill at Titagarh. He used to live in Manirampur. Some of his relatives lived near his house. Since the past few days, no one had seen Das in the area. On Wednesday night, some of his relatives and neighbours saw lights inside his house were on and the doors were open. Also, a foul smell was coming out of his house. Also Read – Bengal family worships Muslim girl as Goddess Durga in Kumari PujaWhen a few of his neighbours went to check his house, they saw Das lying in a pool of blood on the floor with his throat slit. Immediately, Barrackpore police station was informed. During the probe sleuths found the almirahs inside Das’s room were open and valuables had been stolen. Also, three glass and a bottle of liquor was seized from the room. It is suspected that the persons who had killed Das and stole valuables in the house. Das did not get a chance to alert anyone when he was murdered. Till Thursday night, none could be arrested in this case. Also Read – Bengal civic volunteer dies in road mishap on national highwayIn another incident, a youth identified as Mrinmoy Mondal was killed while he was standing outside of his in-law’s house in Nimta. Though he was originally from Gaighata in North 24 Parganas, Mrinmoy used live at Nimta after his marriage. On Wednesday, around 12 am, he was reportedly standing in front of his in-law’s house. All of a sudden some of his neighbours who were standing close to him, saw a person crossing him riding a bicycle and immediately Mrinmoy hit the ground bleeding profusely from his neck. When they got busy to help Mrinmoy, the bicyclist managed to flee the scene. He was declared brought dead by the doctor in a local hospital. It is alleged that the unknown bicyclist killed him. Sleuths are interrogating Mrinmoy’s wife and in-laws to find clues in the case.